rs11794152 - LINC03142 and intelligence
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Key takeaways
- rs11794152 is linked to intelligence based on GWAS data
- The association is modest with an effect size of 0.07 p=1e-9 in about 300 people
- It is part of the LINC03142 locus which may involve brain cell types
Key takeaways
- This variant is linked to intelligence based on GWAS data [PMID 29520040].
- The association is modest with a reported effect size of 0.07 p=1e-9 in about 300 people.
- It is part of the LINC03142 locus which may involve brain cell types.
What the research says The study reports that rs11794152 is associated with intelligence in a meta-analysis of 87,740 individuals. It was identified as one of 18 loci significantly linked to IQ [PMID 29520040].
Reported associations
- Intelligence: The variant is statistically associated with higher IQ scores with an effect size of 0.07 p=1e-9 in about 300 individuals [PMID 29520040].
- Brain cell types: The locus may involve pyramidal neurons and CA1 region of the hippocampus [PMID 29520040].
Evidence quality The evidence comes from a GWAS meta-analysis of 87,740 individuals reporting an effect size of 0.07 p=1e-9 for rs11794152 [PMID 29520040]. This association is modest and not replicated in other studies.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11794152 mean?
rs11794152 is a genetic variant at the LINC03142 locus that has been associated with intelligence in GWAS studies.
Is this variant harmful?
The evidence shows only a small association with IQ and no indication of health risk.