Expressive

rs11794152 - LINC03142

Magnitude 4.5 · 3 studies on file

Reported associations

  • Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status - Unknown journal (n.d.) · Unknown authors · PubMed 34855049

    ABSTRACT: This study aims to disentangle the contribution of genetic liability, educational attainment (EA), and their overlap and interaction in lifetime smoking. We conducted genome-wide association studies (GWASs) in UK Biobank (N = 394,718) to (i) capture variants for lifetime smoking, (ii) variants for EA, and (iii) variants that contribute to lifetime smoking independently from EA ('smoking-without-EA'). Based on the GWASs, three polygenic scores (PGSs) were created for individuals from the Netherlands Twin Register (NTR, N = 17,805) and the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2, N = 3090). We tested gene-environment (G × E) interactions between each PGS, neighborhood socioeconomic status (SES) and EA on lifetime smoking. To assess i

  • Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87 740 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 29520040

    ABSTRACT: Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with brain tissue and single cell gene expression data to identify tissues and cell types associated with intelligence. GWAS data for IQ (N = 78 308) were meta-analyzed with a study comparing 1 247 individuals with mean IQ ~170 to 8 185 controls. Genes associated with intelligence implicate pyramidal neurons of the somatosensory cortex and CA1 region of the hippocampus, and midbrain embryonic GABAergic neurons. Tissue-specific analyses find the most significant enrichment

  • Large-scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets - Unknown journal (n.d.) · Unknown authors · PubMed 29186694

    ABSTRACT: Summary Here, we present a large (N=107,207) genome-wide association study (GWAS) of general cognitive ability (g), further enhanced by combining results with a large-scale GWAS of educational attainment. We identified 70 independent genomic loci associated with GCA. Results showed significant enrichment for genes causing Mendelian disorders with an intellectual disability phenotype. Competitive pathway analysis implicated the biological processes of neurogenesis and synaptic regulation, as well as the gene targets of two pharmacologic agents: cinnarizine, a T-type calcium channel blocker; and LY97241, a potassium channel inhibitor. Transcriptome-wide and epigenome-wide analysis revealed that the implicated loci were enriched for genes expressed across all brain regions (most str

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