rs10156548 (LINC03142): feeling miserable association
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Key takeaways
- rs10156548 is linked to feelings of misery
- the variant has a strong association with depressed affect
- effect sizes are large and p-values very low
Key takeaways rs10156548 is linked to feelings of misery the variant has a strong association with depressed affect effect sizes are large and p-values very low
What the research says This variant is associated with feelings of misery in about 376 thousand individuals PMID 29500382. Another study links it to depressed affect in about 357 thousand people PMID 29942085.
Reported associations Feeling miserable the C allele is associated with a reported effect size of 6.3 p=3e-10 in about 376 thousand individuals [PMID 29500382]. Depressed affect the G allele is associated with an effect size of 0.018 p=3e-13 in about 357 thousand individuals [PMID 29942085].
Evidence quality The evidence comes from two genome-wide association studies that each report a strong association with the variant. Study PMID 29500382 includes 376 thousand individuals and finds an effect size of 6.3 p=3e-10 for feeling miserable. Study PMID 29942085 includes 357 thousand individuals and finds an effect size of 0.018 p=3e-13 for depressed affect. No conflicting findings are reported.
Last lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10156548 mean?
It is a genetic marker at the LINC03142 locus that has been associated with feelings of misery in large population studies.
Is rs10156548 linked to depression?
Yes it is associated with depressed affect according to GWAS data.
Can this variant be used for health monitoring?
It is not a diagnostic marker and no clinical guidance is provided.