LINC02796, variants, traits, and what the research shows

LINC02796 - what this gene does

LINC02796 (long intergenic non-coding RNA 02796 - a class of RNA molecule that does not encode protein but may play regulatory roles in the genome) appears across genome-wide association studies (GWAS - research that scans many people's genomes for variants statistically linked to a trait) in mental health, neurological, metabolic, sleep, and hormonal trait domains.

Key takeaways

• Six variants in this gene independently link to mental health traits - the most concentrated theme in its profile
• Additional associations span neurological function, metabolic health, sleep, and hormonal traits
• The highest-magnitude variants include several with dedicated published research pages
• 141 total variants are catalogued, but most lack detailed study summaries - the evidence picture is still developing
• All associations are population-level GWAS signals, not predictors for any individual

Notable variants

The top-magnitude variants (score 4.50) include a cluster of mental health associations: rs12143162, rs2568952, rs61491549, rs782212, and rs9425089 all carry this trait label. A neurological signal appears at rs12724444, and a metabolic signal at rs527320094. Two additional magnitude-4.50 variants - rs10889966 and rs11210074 - have published research pages but no trait label is available in the current dataset.

Trait associations

Mental health is the most represented domain, with six catalogued variants pointing to it: rs12143162, rs2568952, rs61491549, rs782212, rs9425089, and rs11209948 - convergence across multiple independent variants strengthens the signal relative to any single finding. Neurological associations appear at rs12724444 and rs10889994. Metabolic links surface at rs10789336, rs11209947, rs11209951, and rs527320094. Additional trait domains include sleep (rs111991969, rs112913804), hormonal (rs11209943), and nutritional (rs11209952).

Evidence quality

The strongest on-file signals carry a magnitude score of 4.50 and include variants with dedicated published research pages (rs10889966, rs11210074, rs12143162). A second tier at magnitude 2.20 also contains multiple published-page variants: rs10493500, rs10789336, rs10889994, rs111991969, rs11209943, rs11209947, rs11209948, rs11209951, rs11209952, and rs112913804. Of 141 total catalogued variants, only 29 have prior research summaries; detailed effect sizes, sample sizes, and replication status are not available in the current dataset for most entries, limiting how precisely the strength of individual associations can be characterised.

What this is NOT

These variants are population-level statistical signals identified in large GWAS studies - they describe patterns across groups and cannot predict outcomes for any specific individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation for any action.