rs10789336 - LINC02796

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. - Human molecular genetics (2014) · Graff M, Ngwa JS, Workalemahu T, Homuth G, Schipf S, Teumer A, Völzke H, Wallaschofski H, Abecasis GR, Edward L, Francesco C, Sanna S, Scheet P, Schlessinger D, Sidore C, Xiao X, Wang Z, Chanock SJ, Jacobs KB, Hayes RB, Hu F, Van Dam RM, Crout RJ, Marazita ML, Shaffer JR, Atwood LD, Fox CS, Heard-Costa NL, White C, Choh AC, Czerwinski SA, Demerath EW, Dyer TD, Towne B, Amin N, Oostra BA, Van Duijn CM, Zillikens MC, Esko T, Nelis M, Nikopensius T, Metspalu A, Strachan DP, Monda K, Qi L, North KE, Cupples LA, Gordon-Larsen P, Berndt SI · PubMed 23669352

  Genetic loci for body mass index (BMI) in adolescence and young adulthood, a period of high risk for weight gain, are understudied, yet may yield important insight into the etiology of obesity and early intervention. To identify novel genetic loci and examine the influence of known loci on BMI during this critical time period in late adolescence and early adulthood, we performed a two-stage meta-analysis using 14 genome-wide association studies in populations of European ancestry with data on BMI between ages 16 and 25 in up to 29 880 individuals. We identified seven independent loci (P < 5.0 × 10^-8) near FTO (P = 3.72 × 10^-²³), TMEM18 (P = 3.24 × 10^-¹^7), MC4R (P = 4.41 × 10^-¹^7), TNNI3K (P = 4.32 × 10^-¹¹), SEC16B (P = 6.24 × 10^-9), GNPDA2 (P = 1.11 × 10^-

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