rs11209943 - LINC02796: brain expression and cognitive link

Key takeaways

• This variant is linked to higher brain expression in the cerebellum and cortex.
• It is associated with general cognitive ability, a reported effect size of 6.55, p=6e-11 in about 300 thousand individuals.
• It may influence menarche timing, with an effect size of 3e-21 and a sample of 242 thousand people.
• It affects body size at age ten, reported effect size 0.018, p=9e-38 in about 453 thousand individuals.

What the research says The GWAS catalog shows this variant is linked to general cognitive ability, a reported effect size of 6.55, p=6e-11 in about 300 thousand individuals 29844566. It is also associated with menarche timing, with an effect size of 3e-21 and a sample of 242 thousand people 30595370. Male puberty timing shows an association with this variant, effect size 0.0043, p=1e-6 in 174 thousand individuals 32210231.

Reported associations General cognitive ability: this variant is linked to higher scores, a reported effect size of 6.55, p=6e-11 29844566. Menarche timing: this variant is linked to earlier onset, a reported effect size of 3e-21, p=3e-21 30595370. Male puberty timing: this variant is linked to earlier onset, a reported effect size of 0.0043, p=1e-6 32210231. Body size at age ten: this variant is linked to larger measurements, a reported effect size of 0.018, p=9e-38 32376654.

Evidence quality The evidence comes from four GWAS Catalog associations each with large samples and very low p-values indicating strong statistical significance. The reported effect sizes range from 0.0043 to 6.55, all for the risk allele A [29844566, 30595370, 32210231, 32376654].

Tissue-specific expression effects

• LINC02796: increased expression in Brain_Cerebellar_Hemisphere, Brain_Cerebellum, Brain_Cortex, Brain_Frontal_Cortex_BA9, Nerve_Tibial GTEx Portal.

No lifestyle considerations on file for this variant.