DLG2, variants, traits, and what the research shows

DLG2 - what this gene does

Variants catalogued in this gene span a broad range of trait domains - including neurological, immune, kidney, nutritional, cancer, mental health, and musculoskeletal - though the summaries currently available do not provide sufficient detail to characterize its molecular function.

Key takeaways

• DLG2 variants have been linked to at least eight distinct trait domains, including neurological, immune, kidney, and cancer.
• Two independent kidney-associated variants and two independent neurological variants suggest those signals may be more robust than single-variant findings.
• All top-listed variants in this dataset carry the same evidence magnitude score, indicating a consistent quality threshold across the set.
• Detailed effect sizes and study-level data are not yet available for most variants, so all associations should be treated as preliminary.
• These are population-level statistical associations - they do not predict outcomes for any individual.

Notable variants

Among the highest-priority variants, rs1028775793 is linked to a nutritional trait. Two variants independently point to neurological phenotypes - rs10501570 and rs286043 - the same broad domain appearing in two independent loci adds weight to that signal. Immune-related associations appear in both rs114839353 and rs140761009. Kidney associations are represented by rs117618210 and rs117751000, again two independent variants pointing to the same system. A mental health association is recorded for rs17147674, and cancer-linked variants include rs147995154 and rs149365710.

Trait associations

The trait landscape across documented variants is wide. Neurological traits appear in at least two independent variants - rs10501570 and rs286043 - lending some replication weight to that domain. Kidney associations are similarly reinforced by two independent variants: rs117618210 and rs117751000. Immune phenotypes appear in rs114839353 and rs140761009. Single-variant associations cover nutritional traits (rs1028775793), mental health (rs17147674), musculoskeletal traits (rs148643344), a rare disease phenotype (rs146094436), and cancer (rs147995154, rs149365710, rs34905738). Additional variants - including rs1432054, rs145742114, rs17807909, rs182369593, rs202170665, rs544465873, and rs571769378 - do not yet have published trait metadata.

Evidence quality

Of 189 total variants on file, 20 are listed here and all carry a uniform magnitude score of 4.50. Five - rs10501570, rs114839353, rs117618210, rs117751000, and rs1028775793 - have associated editorial pages from prior research. However, detailed study summaries including sample sizes, odds ratios (measures of how much a variant shifts the statistical likelihood of a trait in a population), and replication status are not available in the current input. Most associations here originate from GWAS (genome-wide association studies - scans of many thousands of people's genomes for variants statistically linked to a trait); without individual study-level data it is not possible to confirm whether findings are single-cohort or multi-cohort, or whether any reach ClinVar-grade clinical classification. The breadth of trait domains is notable but may partly reflect the gene's genomic span rather than a unified biological role. All associations should be treated as preliminary.

What this is NOT

These variants are population-level statistical signals, not deterministic predictors for any individual - carrying a listed variant does not mean a person will develop any associated trait. This page does not prescribe, diagnose, or advise any course of action.