rs1028775793 - DLG2

Magnitude 4.5 · 1 study on file

Reported associations

• Rare-Variant Genome-Wide Association and Polygenic Score Assessment of Vitamin D Status in a Middle Eastern Population - Unknown journal (n.d.) · Unknown authors · PubMed 41096749

  ABSTRACT: Vitamin D deficiency is highly prevalent in the Middle East despite abundant sunlight; however, most genetic studies have focused on common variants in Europeans only. We analyzed whole-genome sequences from 13,808 Qatar Biobank participants, evaluating rare variants (minor allele frequency 0.01-0.0001) for associations with serum 25-hydroxyvitamin D (25(OH)D) levels and deficiency risk (≤20 ng/mL) in independent discovery (n = 5885) and replication (n = 7767) cohorts, followed by meta-analyses. In quantitative analyses, the discovery cohort identified 41 genome-wide significant signals, including CD36 rs192198195 (p = 2.48 × 10−8), and replication found 46, including SLC16A7 rs889439631 (p = 2.19 × 10−8), implicating lipid metabolism pathways. In binary analyses, repli

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