rs12406058 (LINC02869): mitral valve prolapse link
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- rs12406058 is linked to mitral valve prolapse
- it reduces TGFB2 expression in thyroid tissue
- the GWAS effect size is 1.52 with p=1e-10
Key takeaways
- rs12406058 is linked to mitral valve prolapse.
- it reduces TGFB2 expression in thyroid tissue.
- the GWAS effect size is 1.52 with p=1e-10.
What the research says The GWAS shows an association with mitral valve prolapse, risk allele A, effect size 1.52 p=1e-10 PMID 35245370. GTEx data indicates reduced TGFB2 expression in thyroid tissue [GTEx].
Reported associations
- Mitral valve prolapse: the variant is associated with this condition, risk allele A, reported effect size 1.52 p=1e-10 PMID 35245370.
Evidence quality The GWAS used about 439 thousand individuals, the variant has a p-value of 1e-10 and is not replicated in other studies PMID 35245370. The GTEx expression effect is from a cis-window analysis with 953 donors, FDR<0.05 [GTEx].
Tissue- specific expression effects
- GTFB2: reduced expression in thyroid tissue GTEx Portal.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs12406058 mean?
It is a genetic variant associated with mitral valve prolapse and linked to lower TGFB2 expression in thyroid tissue.
Is this variant harmful?
The GWAS shows an association but no direct health risk; it may affect gene expression only.
Can I test for rs12406058?
It is not a clinical diagnostic marker and is not recommended for routine testing.