rs12377846 (BNC2): gut microbiota link
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Key takeaways
- BNC2 is linked to gut microbiota abundance
- The C allele reduces BNC2 expression in fat and skin
- No disease association reported
Key takeaways
- BNC2 is linked to gut microbiota abundance
- The C allele reduces BNC2 expression in fat and skin
- No disease association reported
What the research says The C allele of rs12377846 is associated with higher gut microbiota abundance in a genome-wide association study of about 18 thousand individuals [PMID 33462485]. This variant reduces BNC2 expression in adipose tissue and skin, as shown by GTEx expression quantitative trait loci data [GTEx Portal].
Reported associations
- Gut microbiota abundance: the C allele is associated with higher abundance, reported effect size 4.95 p=7e-7 in about 18 thousand individuals [PMID 33462485].
- BNC2 expression: reduced expression in adipose_visceral_omentum, skin_not_sun_exposed_suprapubic, adipose_subcutaneous, skin_sun_exposed_lower_leg [GTEx Portal].
Evidence quality The GWAS used a sample of about 18 thousand individuals and reported a strong association between the C allele and gut microbiota abundance (effect size 4.95, p=7e-7). The expression data from GTEx shows reduced BNC2 expression in adipose tissue and skin with similar significance. No conflicting findings were found.
Tissue-specific expression effects
- BNC2: the direction is reduced expression followed by tissues list "adipose_visceral_omentum, skin_not_sun_exposed_suprapubic, adipose_subcutaneous, skin_sun_exposed_lower_leg" [GTEx Portal].
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does the rs12377846 variant do?
The C allele is associated with higher gut microbiota abundance and lower BNC2 expression in adipose tissue.
Is this variant linked to disease?
No disease association has been reported for this variant in the provided studies.
Can I change my diet because of this gene?
There are no lifestyle recommendations tied to this variant; it does not affect health outcomes.