rs12195741 - ESR1: peripheral arterial disease link
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- rs12195741 is linked to peripheral arterial disease
- the variant has a reported effect size of 2.5 p=6e-6 in about 2000 people
- risk allele G is associated with higher disease risk
Key takeaways rs12195741 is linked to peripheral arterial disease the variant has a reported effect size of 2.5 p=6e-6 in about 2000 people risk allele G is associated with higher disease risk
What the research says The rs12195741 variant in the ESR1 gene is linked to peripheral arterial disease based on a GWAS catalog study PMID 27082954.
Reported associations Peripheral arterial disease this variant is associated with higher risk in about 2000 individuals with a reported effect size of 2.5 p=6e-6 [PMID 27082954].
Evidence quality The evidence comes from a single GWAS catalog association in roughly 2000 participants reporting an effect size of 2.5 p=6e-6 [PMID 27082954]. No conflicting findings reported.
No lifestyle considerations on file for this variant.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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PAD risk and air pollution exposure assessment Moderate
ESR1 variant associated with 2.5-fold increased PAD risk, particularly in high air pollution
Review baseline cardiovascular assessment and air pollution exposure levels
Lifestyle
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prolonged traffic-related air pollution exposure Moderate
Traffic air pollution amplifies PAD risk conferred by ESR1 rs12195741 G allele
Limit time in high-traffic areas; use air filtration in home and car on high pollution days
Screening
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peripheral arterial disease screening Moderate
G allele confers 2.5-fold PAD risk; effect magnified by traffic-related air pollution
Discuss baseline ankle-brachial index or lower extremity ultrasound with physician
Frequently asked questions
What does rs12195741 mean?
It is a single nucleotide change in the ESR1 gene that has been linked to peripheral arterial disease based on a GWAS catalog study.
Is this variant related to heart health?
Yes it is associated with peripheral arterial disease which affects blood flow and can increase cardiovascular risk.
Can I test for rs12195741 at home?
Home tests may include this SNP but results are not personalized medical advice.