Expressive

rs12195741 - ESR1

Magnitude 4.5 · 1 study on file

Reported associations

  • Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease. - PloS one (2016) · Ward-Caviness CK, Neas LM, Blach C, Haynes CS, LaRocque-Abramson K, Grass E, Dowdy E, Devlin RB, Diaz-Sanchez D, Cascio WE, Lynn Miranda M, Gregory SG, Shah SH, Kraus WE, Hauser ER · PubMed 27082954

    There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing susceptibility to these exposures. However, genome-scale investigations of these interactions have been rarely performed particularly in the case of air pollution exposures. We performed race-stratified genome-wide gene-environment interaction association studies on European-American (EA, N = 1623) and African-American (AA, N = 554) cohorts to investigate the joint influence of common single nucleotide polymorphisms (SNPs) and residential exposure to traffic ("traffic exposure")-a recognized vascular disease risk factor-on peripheral arterial disease (PAD). Traffic exposure was estimated via the distance from the pri

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • PAD risk and air pollution exposure assessment Moderate

    ESR1 variant associated with 2.5-fold increased PAD risk, particularly in high air pollution

    Review baseline cardiovascular assessment and air pollution exposure levels

Lifestyle

  • prolonged traffic-related air pollution exposure Moderate

    Traffic air pollution amplifies PAD risk conferred by ESR1 rs12195741 G allele

    Limit time in high-traffic areas; use air filtration in home and car on high pollution days

Screening

  • peripheral arterial disease screening Moderate

    G allele confers 2.5-fold PAD risk; effect magnified by traffic-related air pollution

    Discuss baseline ankle-brachial index or lower extremity ultrasound with physician