rs12056500 - CSMD1 linked to liver protein quantitative trait
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Key takeaways
- rs12056500 is a common variant linked to liver protein quantitative trait
- The effect size reported is 1.58 with p=3e-8 favoring the C allele
- This association was found in about 287 individuals
- The gene CSMD1 sits at this locus but has no eQTL signal and is not discussed in the studies
Key takeaways
- rs12056500 is a common variant linked to liver protein quantitative trait
- The effect size reported is 1.58 with p=3e-8 favoring the C allele
- This association was found in about 287 individuals
- The gene CSMD1 sits at this locus but has no eQTL signal and is not discussed in the studies
What the research says A genome-wide association study found rs12056500 associated with a protein quantitative trait in the liver [PMID 32778093]. The C allele is linked to higher levels of this protein [PMID 32778093].
Reported associations Liver protein quantitative trait The variant is associated with higher levels of this protein, effect size 1.58 p=3e-8 sample 287 C allele [PMID 32778093].
Evidence quality The association was reported in a single genome-wide association study of about 287 individuals with an effect size of 1.58 and p=3e-8 [PMID 32778093]. Replication beyond this cohort has not been published.
Last lifestyle considerations on file for this variant.
Frequently asked questions
What does rs12056500 mean?
rs12056500 is a common DNA change in the CSMD1 gene that has been linked to higher levels of a protein found in the liver.
Is this variant related to disease?
The study does not report any direct link between rs12056500 and disease; it only associates with a protein quantitative trait.
Can I change my diet because of this?
There is no evidence that the variant affects dietary needs or health outcomes beyond the observed protein association.