rs12025970 (LINC02869): lung function link
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- rs12025970 is linked to a small increase in post-bronchodilator FEV1/FVC ratio
- The variant reduces expression of LINC02869 in the testis
- This association comes from a genome-wide association study of about 13 000 participants
Key takeaways
- rs12025970 is linked to a small increase in post-bronchodilator FEV1/FVC ratio
- The variant reduces expression of LINC02869 in the testis
- This association comes from a genome-wide association study of about 13 000 participants
What the research says rs12025970 is associated with a small increase in post-bronchodilator FEV1/FVC ratio (effect size 0.012, p=2e-6) PMID 26634245 The variant reduces expression of LINC02869 in the testis (slope -0.38, p=5.8e-5) GTEx.
Reported associations Post bronchodilator FEV1/FVC ratio: the variant is associated with a small increase in this measure, reported effect size 0.012, p=2e-6 PMID 26634245
Evidence quality The evidence comes from a genome-wide association study of about 13 000 individuals and reports a small effect (p=2e-6). There are no conflicting findings in the supplied data.
Tissue-specific expression effects
- LINC02869: reduced expression in testis GTEx Portal
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs12025970 do?
It is a small-effect variant that raises FEV1/FVC ratio after bronchodilator and lowers expression in the testis.
Is this gene related to lung disease?
The gene LINC02869 is expressed in the lungs but the variant only shows a small link to function; it does not cause disease.
Can I test for this variant?
Yes you can check your raw DNA file or use services that interpret 23andMe data for this SNP.