rs12023695 (LINC02869): Lung Function & Gene Expression
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- Linked to post bronchodilator lung function ratios in large population studies
- Shows a small but statistically significant effect size
- Modulates LINC02869 expression levels in testicular tissue
- Reflects population correlations rather than direct clinical diagnosis
Key takeaways
- This variant is linked to lung function measurements, specifically the ratio of forced expiratory volume to forced vital capacity after using a bronchodilator.
- Research involving roughly thirteen thousand participants shows a small but statistically significant association with this trait.
- The variant influences gene expression levels in testicular tissue, reducing the output of the LINC02869 transcript.
- Current evidence focuses on population-level statistical links rather than direct clinical diagnosis or treatment guidance.
What the research says Genome-wide association studies have identified a statistical link between rs12023695 and post bronchodilator FEV1/FVC ratio, a standard measure of lung airflow limitation. The analysis included approximately thirteen thousand individuals and found that carrying the effect allele correlates with a reported effect size of 0.012, with a p-value of 1e-6. Independent expression data indicates that this variant also modulates the activity of the LINC02869 gene in specific tissues. PMID 26634245
Reported associations
- Post bronchodilator FEV1/FVC ratio: Carrying the effect allele is associated with a reported effect size of 0.012 in a cohort of about thirteen thousand individuals, reaching a p-value of 1e-6. PMID 26634245
Evidence quality The available evidence derives from a single large-scale analysis encompassing roughly thirteen thousand participants. The reported p-value of 1e-6 meets conventional thresholds for statistical significance in genetic association studies, though the effect size remains modest. Replication across independent cohorts or additional functional validation is not detailed in the supplied data. The findings reflect population-level correlations and do not establish causation or direct clinical utility for individual health decisions. PMID 26634245
Tissue-specific expression effects
- LINC02869: Reduced expression in the testis. GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs12023695 affect?
Research associates this variant with post bronchodilator FEV1/FVC ratio, a standard measurement of lung airflow capacity.
How strong is the genetic link to lung function?
Studies involving roughly thirteen thousand people found a reported effect size of 0.012 with a highly significant p-value of 1e-6.
Does this variant change gene activity?
Yes, expression data indicates it reduces the output of the LINC02869 transcript specifically in testicular tissue.