rs12022585 (LINC02869): Lung Function & Expression Data
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Key takeaways
- Statistical link to post bronchodilator lung function metrics
- Modest effect size of 0.012 observed in roughly 13 thousand participants
- Expression data shows reduced LINC02869 activity in testicular tissue
- Independent replication is needed to confirm long-term stability
Key takeaways
- This variant shows a statistical link to lung function metrics, specifically the post bronchodilator FEV1/FVC ratio.
- The reported effect size is modest, measured at 0.012 with a p-value of 2e-6 across roughly 13 thousand participants.
- Expression data indicates the variant correlates with reduced LINC02869 activity in testicular tissue.
- Current evidence relies on a single catalog entry, so independent replication remains necessary.
What the research says Genome-wide association studies have identified rs12022585 as a locus associated with pulmonary function metrics, particularly the post bronchodilator FEV1/FVC ratio PMID 26634245. The analysis tracked approximately 13 thousand individuals and found a reported effect size of 0.012 with a p-value of 2e-6 for the effect allele A PMID 26634245. Independent validation across diverse populations would strengthen these initial observations.
Reported associations
- Post bronchodilator FEV1/FVC ratio: The variant correlates with changes in this lung function metric, showing a reported effect size of 0.012, p=2e-6, in a cohort of about 13 thousand individuals PMID 26634245.
Evidence quality The available data comes from a single catalog entry involving roughly 13 thousand participants, which provides a solid baseline but leaves replication status unconfirmed PMID 26634245. The p-value of 2e-6 meets standard thresholds for genome-wide significance, yet the reported effect size of 0.012 suggests a very modest contribution to the trait. Without additional independent cohorts or functional follow-up, the precise biological mechanism and long-term stability of this association remain open questions.
Tissue-specific expression effects
- LINC02869: Reduced expression in the testis GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs12022585 affect?
Research associates this variant with post bronchodilator lung function metrics, specifically the FEV1/FVC ratio, alongside tissue-specific expression patterns for the LINC02869 gene.
How strong is the genetic link to lung function?
The reported effect size is modest at 0.012, indicating a small statistical contribution rather than a direct cause of major physiological changes.
Does this variant change how genes work in the body?
Expression data suggests it correlates with reduced activity of the LINC02869 gene in testicular tissue, though the exact downstream biological impact remains under investigation.