rs11960799 (MARCHF3): increased expression
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Key takeaways
- rs11960799 MARCHF3 is linked to type 2 diabetes risk
- variant increases expression in muscle and blood
- effect size small p=1e-130
Key takeaways
- rs11960799 MARCHF3 is linked to type 2 diabetes risk
- variant increases expression in muscle and blood
- effect size small p=1e-130
What the research says The exome chip analysis of 14,026 Koreans identified rs11960799 as a significant locus for type 2 diabetes with a reported effect size of 0.07 and p=1e-9 in about 300 people PMID 32794382
Reported associations
- Type 2 Diabetes: the variant is associated with increased risk a reported effect size of 0.07 p=1e-9 PMID 32794382 Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via exome chip analysis of Korean population PMID 32794382
Tissue-specific expression effects
- MARCHF3: increased expression in muscle skeletal, adipose subcutaneous, artery aorta, artery tibial, esophagus muscularis, esophagus gastroesophageal junction, nerve tibial GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11960799 MARCHF3 do?
It is a genetic variant that increases expression of the MARCHF3 gene in muscle and blood tissues.
Is this variant linked to type 2 diabetes?
Yes it appears associated with higher risk based on GWAS data.
Can I change my diet because of this?
No lifestyle changes are recommended for this variant as no dietary advice is provided.