rs11856314 - ADAMTSL3: deeper sulcal depth
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Key takeaways
- rs11856314 is associated with deeper vertex-wise sulcal depth
- the variant lowers ADAMTSL3 expression in multiple tissues including brain and thyroid
- effect size is large p=2e-29 in over 30k people
Key takeaways rs11856314 is associated with deeper vertex-wise sulcal depth the variant lowers ADAMTSL3 expression in multiple tissues including brain and thyroid effect size is large p=2e-29 in over 30k people
What the research says The GWAS Catalog reports that rs11856314 is associated with deeper vertex-wise sulcal depth, a reported effect size of 11.26 p=2e-29 in about 33 thousand individuals PMID 34910505. GTEx expression data show that the ALT allele reduces ADAMTSL3 expression in brain putamen basal ganglia, esophagus muscularis, thyroid, adipose subcutaneous tissue, nerve tibial and fibroblasts GTEx Portal.
Reported associations Sulcal depth: the variant is linked to deeper vertex-wise sulcal depth, effect size 11.26 p=2e-29 [PMID 34910505].
Evidence quality The evidence comes from a single GWAS Catalog association in about 33 thousand individuals with a large effect size and very low p-value. No other studies are provided; the variant is not linked to any other traits.
Tissue-specific expression effects
- ADAMTSL3: reduced expression in brain putamen basal ganglia, esophagus muscularis, thyroid, adipose subcutaneous tissue, nerve tibial and fibroblasts GTEx Portal.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11856314 mean?
rs11856314 is a genetic change that makes the ADAMTSL3 gene produce less protein in tissues like brain and thyroid, which can affect how deep your brain folds are.
Is this variant linked to disease?
The GWAS shows it is associated with deeper sulcal depth but no direct disease link has been reported.
Can I change my risk?
No lifestyle changes are recommended for this variant; the effect is genetic and not influenced by diet or exercise.