FAM53B variant lowers expression in blood and thyroid
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- FAM53B variant linked to lower whole-blood expression
- Associated with reduced FAM53B levels in blood, thyroid and other tissues
- GWAS shows suggestive link to lifelong premature ejaculation
Key takeaways
- FAM53B variant linked to lower whole-blood expression
- Associated with reduced FAM53B levels in blood, thyroid and other tissues
- GWAS shows suggestive link to lifelong premature ejaculation
What the research says A genome-wide association study of Chinese men found that rs11818135 is linked to a lower risk of lifelong premature ejaculation [PMID 35021295]. The variant also shows reduced expression of FAM53B in whole blood and thyroid [PMID 35021295].
Reported associations
- Premature ejaculation: the variant is associated with lower risk, reported effect size p=5e-6 [PMID 35021295]
Evidence quality The study enrolled 486 Chinese male Han participants with 120 cases and 366 controls, using GWAS to identify 33 variants in 13 genes including rs11818135 [PMID 35021295]. The association is suggestive (p<5×10-6) but not definitive. No replication studies are provided.
Tissue-specific expression effects
- FAM53B: reduced expression in whole blood, thyroid GTEx Portal No lifestyle considerations on file for this variant.
Frequently asked questions
What does the rs11818135 variant do?
The rs11818135 variant is associated with reduced expression of FAM53B in tissues such as whole blood and thyroid.
Is this a health risk?
The evidence shows only a suggestive association with premature ejaculation and no direct health impact reported.
Can I change my lifestyle to affect FAM53B?
No lifestyle considerations are available for this variant.