rs118178404 (HLA-DQA1): Allergen sensitivity
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Key takeaways
- rs118178404 is linked to higher sensitivity to Hevea brasiliensis allergen
- The variant shows increased expression in several tissues like heart and thyroid
- No disease is known to be caused by this common allele
Key takeaways rs118178404 is linked to higher sensitivity to Hevea brasiliensis allergen The variant shows increased expression in several tissues like heart and thyroid No disease is known to be caused by this common allele
What the research says This variant is associated with Allergen component sensitization (Hevea brasiliensis 8) with a reported effect size of 5.53, p=4e-8, based on 564 individuals [37780799]. No other studies report this association.
Reported associations
- Allergen component sensitization: increased sensitivity to Hevea brasiliensis 8 with effect size 5.53, p=4e-8 in about 564 individuals [37780799].
Evidence quality The variant is associated with allergen component sensitization (Hevea brasiliensis 8) with a reported effect size of 5.53, p=4e-8, based on 564 individuals [37780799]. No other studies report this association.
Tissue-specific expression effects
- HLA-DRB6: increased expression in heart atrial appendage, breast tissue, subcutaneous fat, visceral fat, and thyroid GTEx Portal
- HLA-DQA2: increased expression in heart atrial appendage and esophagus gastroesophageal junction GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Hevea brasiliensis (latex) allergen testing Moderate
HLA-DQA1 variants are associated with increased sensitization to natural rubber allergen components, suggesting heightened latex allergy risk
Discuss latex allergy testing with allergist if occupational or clinical exposure risk is present
Frequently asked questions
What does rs118178404 mean?
It is a genetic change in the HLA-DQA1 gene that makes people more sensitive to a plant allergen.
Is this variant linked to disease?
The studies do not show any disease link; it only affects sensitivity and expression.
Can I test for this variant?
Yes, many DNA tests include HLA genes but they are not used for diagnosis.