Expressive

rs118114174 HLA-DQA1 allergen sensitivity

Key takeaways

  • This SNP is linked to higher sensitivity to hevea brasiliensis 8 pollen
  • It may affect immune response to this allergen
  • The G allele increases risk in about 564 people

Key takeaways

  • This SNP is linked to higher sensitivity to hevea brasiliensis 8 pollen
  • It may affect immune response to this allergen
  • The G allele increases risk in about 564 people

What the research says A genome-wide association study found that the G allele of rs118114174 is linked to higher sensitivity to hevea brasiliensis 8 pollen 37780799 GTEx data show that the HLA-DQA2 gene shows increased expression of this allele in several tissues such as breast tissue and esophagus GTex.

Reported associations

  • Allergen component sensitization (Hevea brasiliensis 8): the G allele is linked to higher sensitivity, reported effect size 5.48 p=4e-8 in about 564 individuals 37780799.

Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via GWAS Catalog association [37780799]. The GTEx expression data are separate and not disease-causing.

Tissue-specific expression effects

  • GENE: increased expression in whole blood, breast tissue, esophagus, and thyroid GTex.

Last lifestyle considerations on file for this variant.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • HLA-DQA1 latex sensitization genetic risk Moderate

    HLA-DQA1 rs118114174 G allele associates with 5.48-fold increased Hevea brasiliensis latex allergen sensitization

Screening

  • latex-specific IgE antibody testing Moderate

    HLA-DQA1 rs118114174 G carriers show substantially elevated latex allergen sensitization risk

    Request serum IgE testing for Hevea brasiliensis latex allergen components if not already done

Frequently asked questions

What does rs118114174 mean?

It is a genetic change that can make you more sensitive to pollen from the hevea brasiliensis tree.

Is this variant linked to disease?

The study shows it is associated with higher sensitivity to an allergen but not directly to any disease.

Does this affect how my body expresses HLA-DQA2?

GTEx data indicate the allele leads to increased expression of HLA-DQA2 in tissues like breast tissue and esophagus.