Expressive

rs11774266 (XKR6): lower eGFR

Key takeaways

  • The rs11774266 XKR6 variant is linked to a drop in estimated glomerular filtration rate (eGFR) with an effect size of 7.48, p=7e-14.
  • This variant is a common allele (C) associated with lower eGFR.
  • It is not linked to other health traits in this dataset.

Key takeaways

  • The rs11774266 XKR6 variant is linked to a drop in estimated glomerular filtration rate (eGFR) with an effect size of 7.48, p=7e-14.
  • This variant is a common allele (C) associated with lower eGFR.
  • It is not linked to other health traits in this dataset.

What the research says The rs11774266 XKR6 variant is associated with a lower estimated glomerular filtration rate (eGFR) in humans. [PMID 35710981] This variant shows a reported effect size of 7.48, p=7e-14 in about 1.5 million individuals. [PMID 35710981]

Reported associations Estimated glomerular filtration rate (eGFR): the variant is linked to a drop in eGFR with an effect size of 7.48, p=7e-14 [PMID 35710981]

Evidence quality The GWAS used about 1.5 million individuals and reported a highly significant association (p=7e-14). No other studies in the dataset discuss this variant directly. [PMID 35710981]

Tissue-specific expression effects

  • XKR6: reduced expression in whole blood, atrial appendage, suprapubic skin, and heart atrium GTEx Portal.

Last lifestyle considerations on file for this variant.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Screening

  • kidney function (eGFR) screening Moderate

    genetic variant shows strong association with estimated glomerular filtration rate variation in large population

    obtain baseline eGFR if not recently tested; discuss monitoring interval with healthcare provider

Frequently asked questions

What does rs11774266 mean?

It is a genetic variant in the XKR6 gene that has been linked to lower kidney function.

Is this SNP related to heart disease?

The GWAS data do not show any association with heart disease for this variant.

Can I change my risk by lifestyle?

There are no lifestyle recommendations tied to this variant; it is a common allele without known protective or harmful effects.