MAD1L1 rs11764590 pain susceptibility
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- rs11764590 is a common variant linked to higher pain risk
- The reported effect size is 0.07 p=1e-9 in about 300 people
- No direct disease link is found for this variant
Key takeaways
- rs11764590 is a common variant linked to higher pain risk
- The reported effect size is 0.07 p=1e-9 in about 300 people
- No direct disease link is found for this variant
What the research says The joint GWAS analysis of 17 pain traits identified rs11764590 as a significant risk locus with an effect size of 0.07 p=1e-9 [37844115].
Reported associations
- Chronic pain: the variant is associated with increased susceptibility to chronic pain with a reported effect size of 0.07 p=1e-9 [37844115].
- Pain risk: the same association applies to overall pain risk.
Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via joint analysis of pain GWAS summary statistics. The evidence is preliminary and limited by sample size.
Tissue-specific expression effects
- MRM2: reduced expression in brain cerebellar hemisphere GTEx Portal
- ELFN1: reduced expression in cultured fibroblasts GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does the rs11764590 MAD1L1 variant do?
It is a common genetic change that increases susceptibility to chronic pain but does not cause disease on its own.
Is this variant linked to any specific condition?
The evidence shows an association with higher pain risk but no direct link to a particular disease.
Can I change my lifestyle because of this variant?
There are no lifestyle recommendations tied to this variant as it does not affect substance use or behavior.