HLA-B rs117486637: association with ankylosing spondylitis
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Key takeaways
- This SNP is found in the HLA-B gene and has been linked to ankylosing spondylitis.
- The association was observed in Turkish and Iranian populations with a strong effect size.
- Sample sizes were over 2000 total, giving high statistical power.
Key takeaways
- This SNP is found in the HLA-B gene and has been linked to ankylosing spondylitis.
- The association was observed in Turkish and Iranian populations with a strong effect size.
- Sample sizes were over 2000 total, giving high statistical power.
What the research says rs117486637 is a SNP in HLA-B that shows a strong link to ankylosing spondylitis in Turkish and Iranian cohorts PMID 30946743. The variant had an odds ratio of 31.08 with p=8.62e-91.
Reported associations
- Ankylosing spondylitis: rs117486637 is associated with ankylosing spondylitis in Turkish and Iranian populations (OR 31.08, p=8.62×10-91) PMID 30946743.
Evidence quality The supplied studies include a genome-wide association study in Turkish and Iranian cohorts with sample sizes of 2001 total (1001 AS patients, 1011 controls and 479 AS patients, 830 controls) PMID 30946743. The association is genome-wide significant with p=8.62e-91 and the effect size is large.
Lifestyle considerations No lifestyle considerations on file for this variant.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Ankylosing spondylitis risk assessment and clinical evaluation High
rs117486637 shows extremely strong genetic association with ankylosing spondylitis (OR=31.08, p=8.62e-91), indicating substantially elevated disease susceptibility in carriers.
Discuss AS risk and screening options with a rheumatologist; clinical assessment may include sacroiliac imaging and inflammatory markers if symptoms develop.
Frequently asked questions
What does rs117486637 mean?
It is a genetic variant in the HLA-B gene that has been linked to ankylosing spondylitis.
Is this variant common?
The variant is rare with a minor allele frequency of about 0.5% in these populations.
Can I get tested for it?
Testing for rs117486637 is not offered as a standalone test; it is part of broader HLA-B analysis.