rs117483990 - ATP2B1-AS1 Alzheimer risk
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- This variant is linked to Alzheimer disease and earlier age of onset with a reported effect size of 6.07 p=1e-9 in about 4 thousand individuals
- The allele T is the risk allele for these traits
- It is a splice variant of ATP2B1
Key takeaways
- This variant is linked to Alzheimer disease and earlier age of onset with a reported effect size of 6.07 p=1e-9 in about 4 thousand individuals
- The allele T is the risk allele for these traits
- It is a splice variant of ATP2B1
What the research says This variant rs117483990 is associated with Alzheimer disease and earlier age of onset PMID 26830138. The effect size reported is 6.07 p=1e-9 in about 4 thousand individuals.
Reported associations Alzheimer disease: This variant increases risk for Alzheimer disease with a reported effect size of 6.07 p=1e-9 PMID 26830138. Age of onset: The same variant is linked to earlier age of onset with a reported effect size of 6.07 p=1e-9 PMID 26830138.
Evidence quality The supplied study is a genome wide association study with about 4 thousand individuals reporting an effect size of 6.07 p=1e-9 for Alzheimer disease and age of onset PMID 26830138. No other studies were provided so the evidence is limited to this single GWAS.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs117483990 mean?
rs117483990 is a genetic change in the ATP2B1 gene that has been linked to higher risk for Alzheimer disease and earlier age of onset.
Is this variant common or rare?
The variant is not described as common or rare; it was studied in about 4 thousand individuals with an effect size of 6.07 p=1e-9.
Can I change my risk?
No, the evidence does not suggest that lifestyle changes can alter this genetic association.