rs117483990 - ATP2B1-AS1

Magnitude 4.5 · 1 study on file

Reported associations

• Family-based Association Analyses of Imputed Genotypes Reveal Genome-Wide Significant Association of Alzheimer's disease with OSBPL6, PTPRG and PDCL3 - Unknown journal (n.d.) · Unknown authors · PubMed 26830138

  ABSTRACT: The genetic basis of Alzheimer's disease (AD) is complex and heterogeneous. Over 200 highly penetrant pathogenic variants in the genes APP, PSEN1 and PSEN2 cause a subset of early-onset familial Alzheimer's disease (EOFAD). On the other hand, susceptibility to late-onset forms of AD (LOAD) is indisputably associated to the ε4 allele in the gene APOE, and more recently to variants in more than two-dozen additional genes identified in the large-scale genome-wide association studies (GWAS) and meta-analyses reports. Taken together however, although the heritability in AD is estimated to be as high as 80%, a large proportion of the underlying genetic factors still remain to be elucidated. In this study we performed a systematic family-based genome-wide association and meta-analysis

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.