Expressive

rs117375124 HLA-DQA1 allergen sensitization

Key takeaways

  • The rs117375124 HLA-DQA1 variant is linked to higher risk of allergen component sensitization.
  • GWAS shows a strong association with Hevea brasiliensis 8, effect size 5.48 p=4e-8 in about 564 people.
  • This variant increases expression of HLA-DRB6 and HLA-DQA2 in multiple tissues.

Key takeaways

  • The rs117375124 HLA-DQA1 variant is linked to higher risk of allergen component sensitization.
  • GWAS shows a strong association with Hevea brasiliensis 8, effect size 5.48 p=4e-8 in about 564 people.
  • This variant increases expression of HLA-DRB6 and HLA-DQA2 in multiple tissues.

What the research says The rs117375124 HLA-DQA1 variant is associated with allergen component sensitization, specifically Hevea brasiliensis 8, with a reported effect size of 5.48 p=4e-8 in about 564 individuals PMID 37780799. This association was observed across multiple tissues where the variant increases expression of HLA-DRB6 and HLA-DQA2.

Reported associations

  • Allergen component sensitization (Hevea brasiliensis 8) - the variant increases risk with a reported effect size of 5.48 p=4e-8 in about 564 individuals [PMID 37780799].

Evidence quality The GWAS used 564 individuals, yielding a strong association (p=4e-8). No replication studies are provided; the evidence is limited to this single cohort [PMID 37780799].

Tissue-specific expression effects

  • HLA-DRB6: increased expression in whole blood, aorta, and thyroid GTEx Portal
  • HLA-DQA2: increased expression in breast mammary tissue, esophagus gastroesophageal junction GTEx Portal

No lifestyle considerations on file for this variant.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Lifestyle

  • latex exposure Moderate

    HLA-DQA1 variant increases susceptibility to Hevea brasiliensis allergen sensitization and latex allergy

    Use latex-free alternatives; inform healthcare providers of allergy risk

Screening

  • latex allergy testing Moderate

    Genetic variant rs117375124 is associated with increased susceptibility to Hevea brasiliensis component sensitization

    IgE testing for Hevea brasiliensis or latex-specific IgE

Frequently asked questions

What does rs117375124 mean?

It is a genetic variant in the HLA-DQA1 gene that has been linked to higher risk of allergen component sensitization.

Is this variant dangerous?

The study shows an association with allergy, not causation; it does not cause disease on its own.

Does this affect my health?

No evidence suggests it leads to illness; the effect is limited to sensitivity.