rs117353881 - HLA-DQA1: Allergen sensitization
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- The rs117353881 variant is linked to higher risk of Hevea brasiliensis 8 allergy
- It has a small effect size in about half a thousand people
- The link is seen in the HLA-DQA1 gene region
Key takeaways The rs117353881 variant is linked to higher risk of Hevea brasiliensis 8 allergy It has a small effect size in about half a thousand people The link is seen in the HLA-DQA1 gene region
What the research says This variant is associated with Allergen component sensitization (Hevea brasiliensis 8) reported effect size 5.53 p=4e-8 risk allele A PMID 37780799
Reported associations Allergen component sensitization: the variant is associated with increased risk of Hevea brasiliensis 8 allergen sensitivity reported effect size 5.53 p=4e-8 in about 564 individuals risk allele A [PMID 37780799].
Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via GWAS Catalog PMID 37780799.
Tissue- specific expression effects
- HLA-DQA2: increased expression in whole blood, aorta, and thyroid GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
-
uncontrolled occupational latex exposure Moderate
Genetic predisposition to latex sensitization is amplified by occupational exposure in healthcare and similar settings
If in high-latex occupations, use latex-free alternatives and discuss preventive measures with occupational health
Screening
-
latex allergen component sensitization testing Moderate
This HLA-DQA1 variant shows strong genetic association with sensitization to Hevea brasiliensis latex allergen components
Consult allergist for specific IgE testing to Hev b components
Frequently asked questions
What does rs117353881 mean?
It is a change in one DNA letter that can increase allergy risk.
Is this variant linked to Hevea brasiliensis 8 allergy?
Yes studies show it raises the chance of reacting to that allergen.
Can I test for this variant at home?
You can check your raw DNA file with tools like Promethease or SelfDecode but results vary.