rs116550525 - LRP1B

Magnitude 4.5 · 1 study on file

Reported associations

• Metabolomic architecture of obesity implicates metabolonic lactone sulfate in cardiometabolic disease - Unknown journal (n.d.) · Unknown authors · PubMed 34563731

  ABSTRACT: Objective Identify and characterize circulating metabolite profiles associated with adiposity to inform precision medicine. Methods Untargeted plasma metabolomic profiles in the Insulin Resistance Atherosclerosis Family Study (IRASFS) Mexican American cohort (n = 1108) were analyzed for association with anthropometric (body mass index, BMI; waist circumference, WC; waist-to-hip ratio, WHR) and computed tomography measures (visceral adipose tissue, VAT; subcutaneous adipose tissue, SAT; visceral-to-subcutaneous ratio, VSR) of adiposity. Genetic data, inclusive of genome-wide array-based genotyping, whole exome sequencing (WES) and whole genome sequencing (WGS), were evaluated to identify the genetic contributors. Phenotypic and genetic association signals were replicated across

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