Expressive

rs116465573 HDAC9 and Blood Pressure

Key takeaways

  • Systolic blood pressure is linked to this variant with a reported effect size of 7.7 p=5e-6 in about ten thousand individuals
  • The G allele is associated with higher risk
  • This association comes from the GWAS Catalog study

Key takeaways

  • Systolic blood pressure is linked to this variant with a reported effect size of 7.7 p=5e-6 in about ten thousand individuals
  • The G allele is associated with higher risk
  • This association comes from the GWAS Catalog study

What the research says This variant rs116465573 at HDAC9 is linked to Systolic blood pressure a reported effect size of 7.7 p=5e-6 in about ten thousand individuals [PMID 38104120].

Reported associations

  • Systolic blood pressure: this variant increases the trait value by a reported effect size of 7.7 p=5e-6 in about ten thousand individuals
  • Risk allele G: carriers have higher risk as indicated by the same effect size and p-value

Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via GWAS Catalog association [PMID 38104120]. No lifestyle considerations on file for this variant.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Sodium intake Moderate

    Dietary sodium significantly affects blood pressure regulation; reduced intake helps manage hypertension risk

    Aim for <2300 mg daily, or <1500 mg for optimal BP control

Discuss with your doctor

  • Cardiovascular risk assessment with rs116465573 variant Moderate

    This SNP is associated with increased systolic blood pressure, a major cardiovascular risk factor

Lifestyle

  • Regular aerobic exercise Moderate

    Physical activity lowers blood pressure; particularly important for those with genetic predisposition to elevated systolic BP

    150 minutes moderate-intensity aerobic exercise per week

Screening

  • Blood pressure monitoring Moderate

    rs116465573 risk allele G is associated with 7.7 mmHg increase in systolic blood pressure

    Check blood pressure annually or as recommended by healthcare provider

Frequently asked questions

What does rs116465573 mean?

It is a genetic variant at the HDAC9 gene that has been linked to higher Systolic blood pressure in a large study with a small effect size p=5e-6

Is this variant dangerous?

The evidence shows only a modest association with Blood Pressure not enough to be considered high risk

Can I change my diet because of this?

No dietary advice is given for this variant as no lifestyle considerations are available