rs116388828 - WHAMMP2 - PDCD6IPP2

Key takeaways

• The rs116388828 variant is linked to a specific pattern in right eye retinal imaging.
• This pattern also appears in left eye retinal imaging with a slightly different effect size.
• Both associations are strong, with p-values below 0.001.

What the research says The rs116388828 variant is associated with a specific pattern in right eye retinal imaging, reported effect size 3.2 p=6e-10 PMID 38728357. It is also linked to a pattern in left eye retinal imaging, reported effect size 2.99 p=2e-8 PMID 38728357.

Reported associations

• Right eye retinal fundus image self-supervised embedding: this variant changes the pattern, reported effect size 3.2 p=6e-10 PMID 38728357
• Left eye retinal fundus image self-supervised embedding: this variant changes the pattern, reported effect size 2.99 p=2e-8 PMID 38728357

Evidence quality The variant is associated with right eye retinal fundus image self-supervised embedding endophenotype in about 64 thousand individuals with effect size 3.2 p=6e-10 [PMID 38728357] and left eye retinal fundus image self-supervised embedding endophenotype in about 65 thousand individuals with effect size 2.99 p=2e-8 [PMID 38728357]. The evidence is strong, well replicated across the same dataset.

Last lifestyle considerations on file for this variant.