rs116232857 - HLA-DQA1: Sjögren's risk
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Key takeaways
- rs116232857 is linked to Sjögren's syndrome
- the variant has a very low p-value of 1.33e-96 in European ancestry studies
- it sits near HLA-DQA1 and HLA-DRA genes
Key takeaways
- rs116232857 is linked to Sjögren's syndrome
- the variant has a very low p-value of 1.33e-96 in European ancestry studies
- it sits near HLA-DQA1 and HLA-DRA genes
What the research says rs116232857 is associated with Sjögren's syndrome [PMID 24097067]. the variant has a p-value of 1.33e-96 in European ancestry studies [PMID 24097067].
Reported associations
- Sjögren's syndrome: rs116232857 is associated with Sjögren's syndrome, p-value 1.33e-96 [PMID 24097067].
Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via HLA region analysis in PMID 24097067.
Last lifestyle considerations on file for this variant.
Frequently asked questions
What does the rs116232857 variant mean?
rs116232857 is a rare allele in the HLA-DQA1 region that has been linked to Sjögren's syndrome with a p-value of 1.33e-96.
Is this variant common?
No, rs116232857 is not a common allele; it appears only in the HLA region and has a very low frequency in European ancestry studies.
Can I test for this variant?
Testing for rs116232857 would require a DNA analysis that includes the HLA-DQA1 region; standard panels may not capture it.