rs11611208 - PDE3A: height association
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Key takeaways
- rs11611208 variant A allele is linked to height
- The effect size reported is 11.4 p=2e-6 in about 30 thousand individuals
- PDE3A expression is increased in fibroblasts
Key takeaways
- rs11611208 variant A allele is linked to height
- The effect size reported is 11.4 p=2e-6 in about 30 thousand individuals
- PDE3A expression is increased in fibroblasts
What the research says The GWAS Catalog shows rs11611208 variant A allele is associated with height, reported effect size 11.4 p=2e-6 in about 30 thousand individuals [PMID 18391951]. PDE3A expression is increased in fibroblasts, slope +0.19 (p=1.7e-4) [GTEx].
Reported associations Height: the variant A allele is associated with height, reported effect size 11.4 p=2e-6 in about 30 thousand individuals [PMID 18391951].
Evidence quality The GWAS used a sample of about 30 thousand individuals and found the variant A allele associated with height, p=2e-6. The association is significant but modest. No other traits were reported for this rsid in the provided data [PMID 18391951].
Tissue-specific expression effects
- PDE3A: increased expression in fibroblasts [GTEx Portal]
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11611208 mean?
It is a single nucleotide change in the PDE3A gene that has been associated with height and also increases expression of the gene in fibroblasts.
Is this variant related to disease?
No, the GWAS shows only an association with height; there are no known disease effects reported for rs11611208.
Can I change my height by taking supplements?
There is no evidence that supplements affect this variant or its effect on height.