rs11549465 HIF1A and chemo response
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- rs11549465 is linked to a worse chemotherapy response in mesothelioma patients
- The effect size is reported as 0.37 with p=0.044 after adjustment
- Only rs11549465 shows association; other SNPs are not significant
- No impact on survival or progression free survival
Key takeaways
- rs11549465 is linked to a worse chemotherapy response in mesothelioma patients
- The effect size is reported as 0.37 with p=0.044 after adjustment
- Only rs11549465 shows association; other SNPs are not significant
- No impact on survival or progression free survival
What the research says rs11549465 in the HIF1A gene is linked to a worse response to chemotherapy in mesothelioma patients [PMID 40959922].
Reported associations
- Chemotherapy response: variant CT genotype associated with decreased response to cisplatin gemcitabine pemetrexed compared to CC genotype (effect size 0.37 p=0.044) [PMID 40959922]
- Progression free survival: variant CT genotype associated with decreased progression free survival when treated with axitinib or sorafenib in people with Carcinoma Renal Cell compared to CC genotype [PMID 25816720]
Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via PMID 40959922.
Drug response and pharmacogenomics
- CC genotype: increased progression free survival with axitinib or sorafenib in Carcinoma Renal Cell [PMID 25816720]
- CT genotype: decreased progression free survival with axitinib or sorafenib in Carcinoma Renal Cell compared to CC [PMID 25816720]
- TT genotype: decreased progression free survival with axitinib or sorafenib in Carcinoma Renal Cell compared to CC [PMID 25816720]
Tissue-specific expression effects
- HIF1A-AS3: reduced expression in Artery_Tibial GTEx Portal
- LINC03033: increased expression in Muscle_Skeletal, Skin_Sun_Exposed_Lower_leg GTEx Portal
- ENSG00000288928: reduced expression in Artery_Tibial GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does the HIF1A gene do?
The HIF1A gene produces a protein that helps cells adapt to low oxygen levels and can influence how they respond to cancer treatments.
Is rs11549465 linked to mesothelioma?
Yes, the variant is associated with a worse response to chemotherapy in mesothelioma patients according to the study.
Does this SNP affect survival?
The studies do not show any effect on overall or progression free survival for rs11549465.