rs113983785 (ATP2B1-AS1): slower heart rate in heart failure
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Key takeaways
- This SNP is linked to slower heart rate in people with heart failure.
- The effect was small but statistically significant.
- It affects a gene involved in muscle contraction.
- Only about 1000 individuals were studied.
Key takeaways
- This SNP is linked to slower heart rate in people with heart failure.
- The effect was small but statistically significant.
- It affects a gene involved in muscle contraction.
- Only about 1000 individuals were studied.
What the research says The GWAS catalog reports that rs113983785 is associated with slower heart rate in individuals with heart failure with reduced ejection fraction. PMID 31113495 The reported effect size was 10.02, p=6e-6, based on about 1 thousand participants. PMID 31113495.
Reported associations Heart rate slower heart rate in people with heart failure, reported effect size 10.02 p=6e-6 PMID 31113495.
Evidence quality The evidence comes from a single GWAS catalog association with about 1 thousand individuals and a reported effect size of 10.02, p=6e-6. The finding is statistically significant but the sample size is modest and there are no follow-up studies to confirm it. PMID 31113495.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs113983785 do?
It is a genetic variant that has been linked to slower heart rate in individuals with heart failure, based on a GWAS study.
Is this variant harmful?
The association is small and not directly harmful; it only appears in the context of heart failure.
Can I change my risk?
No specific action is recommended; the effect size is modest and no lifestyle changes are tied to this SNP.