rs11208766 - PDE4B: Substance Use Disorder Link
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- rs11208766 is a common variant in PDE4B linked to substance use disorder
- the risk allele A has a reported effect size of 6.34 and p-value 2e-10
- this association was found in a genome wide association study with about 1.5 million participants
Key takeaways
- rs11208766 is a common variant in PDE4B linked to substance use disorder
- the risk allele A has a reported effect size of 6.34 and p-value 2e-10
- this association was found in a genome wide association study with about 1.5 million participants
What the research says The GWAS Catalog reports that rs11208766 is associated with substance use disorder, with the risk allele A showing a reported effect size of 6.34 and p=2e-10 PMID 41057643.
Reported associations
- Substance use disorder: The variant is associated with substance use disorder, with the risk allele A having a reported effect size of 6.34 and p=2e-10 [PMID 41057643].
Evidence quality The evidence comes from a single GWAS Catalog association involving about 1.5 million individuals and reports an effect size of 6.34 with p=2e-10 [PMID 41057643]. The variant is common and the association is statistically significant but replication beyond this study has not been reported.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11208766 mean?
rs11208766 is a common variant in the PDE4B gene that has been linked to substance use disorder, with the risk allele A showing an effect size of 6.34 and p=2e-10.
Is this variant harmful?
The evidence shows a statistical association between rs11208766 and substance use disorder but does not indicate that the variant causes harm or benefit on its own.
Can I change my risk?
Genetic variants are not actionable; they describe associations, not personal health advice.