rs111854640 (Brain White Matter): Structural Association
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Key takeaways
- Statistically linked to brain white matter structure differences
- Reported effect size of 0.49 in a cohort of 32 thousand
- Highly significant p-value of 2e-53
- Based on a single large-scale genomic study
- Correlation does not imply direct cause or individual risk
Key takeaways
- The variant rs111854640 shows a statistical association with differences in brain white matter structure.
- Research documents a reported effect size of 0.49, p=2e-53, in about 32 thousand individuals.
- Findings originate from a single large-scale genomic study without independent replication details.
What the research says Genome-wide association studies have identified rs111854640 as a locus linked to variations in brain white matter structure. The available data documents a reported effect size of 0.49, p=2e-53, in about 32 thousand individuals PMID 41044200. This association highlights how common genetic variation correlates with structural differences in neural tissue.
Reported associations
- Brain age gap derived from white matter: The variant is statistically associated with differences in a metric that compares actual biological age to chronological age using white matter imaging data. The study documents a reported effect size of 0.49, p=2e-53, in about 32 thousand individuals PMID 41044200.
Evidence quality The current evidence rests on a single large-scale genome-wide association study published under PMID 41044200. The sample size of approximately 32 thousand individuals provides substantial statistical power, and the reported p-value of 2e-53 falls well below standard thresholds for genome-wide significance. However, the analysis relies on one primary dataset, and independent replication across diverse populations has not been detailed in the supplied materials. The reported effect size of 0.49 reflects a measurable correlation, but the clinical or functional implications for everyday brain health remain unclear without further longitudinal research.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs111854640 affect?
Research links this variant to measurable differences in brain white matter structure, which supports neural communication and cognitive function.
Is rs111854640 a disease-causing mutation?
No. It is a common genetic variant associated with normal structural variation in brain tissue, not a direct cause of neurological disease.
How was the link between rs111854640 and brain structure discovered?
Scientists identified the association through a large-scale genome-wide study analyzing imaging data from roughly 32 thousand participants.
Can this variant predict my brain health?
Genetic associations show population-level trends, not individual predictions. This variant explains a small fraction of structural variation and does not determine personal outcomes.