rs111371067 - ATP2B1-AS1

Magnitude 4.5 · 1 study on file

Reported associations

• Genetics of heart rate in heart failure patients (GenHRate). - Human genomics (2020) · Evans KL, Wirtz HS, Li J, She R, Maya J, Gui H, Hamer A, Depre C, Lanfear DE · PubMed 31113495

  Elevated resting heart rate (HR) is a risk factor and therapeutic target in patients with heart failure (HF) and reduced ejection fraction (HFrEF). Previous studies indicate a genetic contribution to HR in population samples but there is little data in patients with HFrEF. Patients who met Framingham criteria for HF and had an ejection fraction < 50% were prospectively enrolled in a genetic HF registry (2007-2015, n = 1060). All participants donated blood for DNA and underwent genome-wide genotyping with additional variants called via imputation. We performed testing of previously identified variant "hits" (43 loci) as well as a genome-wide association (GWAS) of HR, adjusted for race, using Efficient Mixed-Model Association Expedited (EMMAX). The cohort was 35% female, 51% African Ame

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