CSMD1 rs11136774: longevity link?
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- This variant is in CSMD1, a gene with limited known function.
- No direct health trait associations are reported.
- PAICSP4 expression is reduced in testis.
Key takeaways
- This variant is in CSMD1, a gene with limited known function.
- No direct health trait associations are reported.
- PAICSP4 expression is reduced in testis.
What the research says The provided longevity GWAS does not mention rs11136774 [PMID 30294719].
Reported associations
- No trait or condition is linked to this variant.
Evidence quality The study used a sex-specific genome-wide association design with 564 male and 1614 female centenarians compared to 773 male and 1526 female controls aged 40-64, yielding p-values below 1e-5 for many loci [PMID 30294719].
Tissue-specific expression effects
- PAICSP4: reduced expression in testis GTEx Portal.
Last lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11136774 do?
rs11136774 is a genetic variant located in the CSMD1 gene and has no known health effects.
Is this variant linked to longevity?
The provided studies do not show any link between rs11136774 and longevity.
Does it affect PAICSP4 expression?
Yes, GTEx data shows reduced PAICSP4 expression in testis.