rs11127876 (CADM2): linked to early-onset bipolar I
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Key takeaways
- rs11127876 is linked to early-onset bipolar I disorder
- the variant raises CADM2 levels in several tissues
- replication shows a strong statistical signal
Key takeaways
- rs11127876 is linked to early-onset bipolar I disorder
- the variant raises CADM2 levels in several tissues
- replication shows a strong statistical signal
What the research says A genome-wide association study found rs11127876 in CADM2 associated with early-onset bipolar I disorder (p=5.19×10-8). [PMID 34016946]. GTEx data show the variant increases CADM2 expression in brain, muscle and adipose tissue. GTEx Portal.
Reported associations
- Early-onset bipolar I disorder: the variant increases risk with a reported effect size of 5.19×10-8, p=0.0354 in replication cohort [PMID 34016946].
Evidence quality The study used 1779 patients and 1060 controls in discovery followed by independent replication with 473 early-onset and 620 non-early-onset participants. The meta-analysis gave a p=5.19×10-8 indicating strong association. No conflicting results were reported. [PMID 34016946].
Tissue-specific expression effects
- CADM2: increased expression whole blood, aorta, and thyroid GTEx Portal.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11127876 mean?
It is a DNA change in the CADM2 gene that has been linked to early-onset bipolar I disorder.
Does this affect how much CADM2 is made?
GTEx data show the variant increases CADM2 expression in brain, muscle and fat tissue.
Is this a common variant?
The study found it rare with a p-value of 5.19×10-8 indicating strong association but not necessarily high frequency.