rs11123816 - AFF3: intelligence and autism link
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- rs11123816 is associated with higher intelligence scores
- rs11123816 is linked to attention deficit hyperactivity disorder or autism spectrum disorder
- This variant increases AFF3 expression in brain and fat tissue
Key takeaways
- rs11123816 is associated with higher intelligence scores
- rs11123816 is linked to attention deficit hyperactivity disorder or autism spectrum disorder
- This variant increases AFF3 expression in brain and fat tissue
What the research says This variant is associated with Intelligence, reported effect size 6.64, p=3e-11, in about 269 thousand individuals, risk/effect allele A.[29942086] This variant is also linked to Attention deficit hyperactivity disorder or autism spectrum disorder or intelligence, pleiotropy, p=5e-10, in about 371 thousand individuals.[35764056]
Reported associations Intelligence: the variant is associated with higher Intelligence scores, a reported effect size of 6.64, p=3e-11, in about 269 thousand individuals.[29942086] Attention deficit hyperactivity disorder or autism spectrum disorder: this variant is linked to Attention deficit hyperactivity disorder or autism spectrum disorder or intelligence, pleiotropy, p=5e-10, in about 371 thousand individuals.[35764056]
Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via GWAS Catalog associations. [29942086] [35764056].
Tissue-specific expression effects
- AFF3: increased expression in whole blood, aorta, thyroid, brain cortex, frontal cortex BA9, anterior cingulate cortex BA24, cerebellum, nucleus accumbens basal ganglia, cerebellar hemisphere.GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11123816 mean?
It is a genetic variant in the AFF3 gene that has been linked to higher intelligence and to attention-deficit/hyperactivity disorder or autism spectrum disorder.
Does this variant affect health?
The studies show it is associated with cognitive traits but no direct health condition is reported.
Is rs11123816 a risk allele for disease?
It is not identified as a disease-causing allele; the effect is on intelligence and behavior traits rather than pathology.