rs11118118 (LINC02869): lung function link
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Key takeaways
- rs11118118 may be linked to better lung function after a bronchodilator
- the T allele is connected to a small increase in FEV1/FVC ratio
- this variant shows lower expression of LINC02869 in testes
Key takeaways
- rs11118118 may be linked to better lung function after a bronchodilator
- the T allele is connected to a small increase in FEV1/FVC ratio
- this variant shows lower expression of LINC02869 in testes
What the research says A genome-wide association study found that the T allele of rs11118118 is associated with a post bronchodilator FEV1/FVC ratio effect size 0.012 p=1e-6 in about 13 thousand individuals [PMID 26634245]. GTEx expression data show reduced LINC02869 expression in the testis for this variant [GTEx]
Reported associations Post bronchodilator FEV1/FVC ratio: the T allele is linked to a small increase in this measure effect size 0.012 p=1e-6 [PMID 26634245]. LINC02869 expression: reduced in the testis for the T allele [GTEx]
Evidence quality The GWAS used about 13 thousand individuals and reported a p-value of 1e-6 indicating strong association. The GTEx data are from 953 donors with a cis window and FDR<0.05 showing a negative slope in testis. No other studies discuss this variant directly.
Tissue-specific expression effects
- LINC02869: reduced expression in the testis GTEx Portal.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11118118 mean?
It is a genetic change in the LINC02869 gene that may affect lung function after using a bronchodilator and also lower expression of the gene in testes.
Is this variant linked to asthma?
The T allele is associated with a small increase in FEV1/FVC ratio which can indicate better airway function but it does not diagnose asthma.
Does LINC02869 affect other tissues?
GTEx data show reduced expression only in the testis; no effect reported elsewhere.