rs11105468 - magnesium link and ATP2B1 reduction
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- Magnesium levels: the variant is linked to lower magnesium levels reported effect size 3.4e-11 p=3.4e-11.
- ATP2B1 expression: reduced expression in Nerve_Tibial tissue.
Key takeaways
- Magnesium levels: the variant is linked to lower magnesium levels reported effect size 3.4e-11 p=3.4e-11 [25344690].
- ATP2B1 expression: reduced expression in Nerve_Tibial tissue [GTEx].
What the research says The study found rs11105468 located at 12q21.33 associated with magnesium levels and also shows reduced ATP2B1 expression in nerve tibial tissue.
Reported associations
- Magnesium levels: the variant is linked to lower magnesium levels reported effect size 3.4e-11 p=3.4e-11 [25344690].
Evidence quality The discovery study used genome-wide association scans with sample sizes of about 8 million variants and genome-wide significance threshold P<1.25×10-8; the variant shows a genome-wide p=3.4e-11 [25344690].
Tissue-specific expression effects
- ATP2B1: reduced expression in Nerve_Tibial tissue [GTEx]. Last lifestyle considerations on file for this variant.
Frequently asked questions
What does rs11105468 do?
It is a genetic variant at the 12q21.33 region that has been associated with lower magnesium levels and reduced ATP2B1 expression in nerve tissue.
Is this variant related to disease?
The evidence shows only an association with magnesium levels; no direct disease link is reported.
Can I test for this variant?
Yes, it can be included in standard genetic panels that cover the 12q21.33 region.