rs11003048 - LNCAROD fracture risk

Key takeaways

• rs11003048 is linked to fracture risk
• rs11003048 lowers bone mineral density in the spine
• rs11003048 reduces bone mineral density mean

What the research says This variant is linked to fracture risk [PMID 30598549]. It also affects bone mineral density in the spine [PMID 34673960] and reduces the mean bone mineral density [PMID 37500982].

Reported associations

• Fracture this variant is associated with fracture risk a reported effect size of 0.078 p=8e-58 in about 426 thousand individuals [PMID 30598549].
• Bone mineral density spine this variant is associated with lower bone mineral density the reported p-value is 9e-11 in about 30 thousand individuals [PMID 34673960].
• Bone mineral density mean this variant is associated with reduced bone mineral density mean the reported p-value is 1e-25 in about 141 thousand individuals [PMID 37500982].

Evidence quality Evidence comes from three GWAS Catalog associations with sample sizes of 426k for fracture risk, 30k and 141k for bone mineral density spine and mean respectively. All p-values are below 1e-9 indicating strong statistical significance. No conflicting findings were reported.

Lifestyle considerations No lifestyle considerations on file for this variant.