rs11003047 LNCAROD fracture risk
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Key takeaways
- rs11003047 is linked to higher fracture risk
- the odds ratio reported is 1.55 with p=1.5e-68
- all identified loci also affect bone mineral density
Key takeaways
- rs11003047 is linked to higher fracture risk
- the odds ratio reported is 1.55 with p=1.5e-68
- all identified loci also affect bone mineral density
What the research says This variant is one of 15 genetic determinants identified in a genome-wide association meta-analysis for fracture risk and also influences bone mineral density [PMID 30158200]. The study found that each standard deviation decrease in genetically determined BMD was linked to a 55% increase in fracture risk via an odds ratio of 1.55, p=1.5×10-68 [PMID 30158200].
Reported associations Fracture risk: this variant is linked to higher fracture risk with an odds ratio of 1.55 (p=1.5×10-68) [PMID 30158200]
Evidence quality The discovery set included 37,857 fracture cases and 227,116 controls; replication in the GENOMOS consortium of 18,779 cases and 32,078 controls was performed. No conflicting findings were reported [PMID 30158200]. No lifestyle considerations on file for this variant.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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Resistance training Low
Grip strength has causal protective effect on fracture risk; resistance training increases grip strength and bone mineral density.
2-3 sessions per week of resistance or weight-bearing exercise
Screening
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Bone mineral density screening Moderate
Bone mineral density is the primary genetic determinant of fracture risk; this SNP influences fracture risk through BMD.
Consider baseline DEXA scan to establish bone density status
Frequently asked questions
What does rs11003047 mean?
It is a genetic marker at the LNCAROD locus that has been associated with higher fracture risk in large studies.
Is this variant linked to bone mineral density?
Yes, the study found it also influences BMD.
Can I change my lifestyle based on this result?
No specific lifestyle advice is provided for this variant.