rs11003047 - LNCAROD
Magnitude 2.2 · 1 study on file
Reported associations
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Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study - Unknown journal (n.d.) · Unknown authors · PubMed 30158200
ABSTRACT: Abstract Objectives To identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide association studies (GWAS) and a two-sample mendelian randomisation approach. Setting 25 cohorts from Europe, United States, east Asia, and Australia with genome wide genotyping and fracture data. Participants A discovery set of 37 857 fracture cases and 227 116 controls; with replication in up to 147 200 fracture cases and 150 085 controls. Fracture cases were defined as individuals (>18 years old) who had fractures at any skeletal site confirmed by medical, radiological, or questionnaire reports. Instrumental variable analyses were performed to estimate effects of 15 selected clinical
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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Resistance training Low
Grip strength has causal protective effect on fracture risk; resistance training increases grip strength and bone mineral density.
2-3 sessions per week of resistance or weight-bearing exercise
Screening
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Bone mineral density screening Moderate
Bone mineral density is the primary genetic determinant of fracture risk; this SNP influences fracture risk through BMD.
Consider baseline DEXA scan to establish bone density status