rs10978481 (LINC01505): eudaimonic well-being link
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Key takeaways
- rs10978481 is linked to higher eudaimonic well-being
- The C allele shows a small effect size p=4e-7 in ~108k people
- This association is reported by the GWAS Catalog
Key takeaways rs10978481 is linked to higher eudaimonic well-being, the C allele shows a small effect size p=4e-7 in about 108 thousand individuals, this association is reported by the GWAS Catalog.
What the research says The GWAS Catalog reports that the rs10978481 C allele is associated with eudaimonic well-being, with an effect size of 5.09 and p=4e-7 in about 108 thousand individuals [PMID 30279531]. The risk allele C is the variant that shows this association [PMID 30279531].
Reported associations Eudaimonic well-being the rs10978481 C allele is associated with higher scores, reported effect size 5.09 p=4e-7 in about 108 thousand individuals [PMID 30279531].
Evidence quality The evidence comes from a genome-wide association study of roughly 108 thousand participants, reporting a small but statistically significant effect size of 5.09 and p=4e-7 for the C allele [PMID 30279531]. No other studies are cited in this catalog entry.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10978481 mean?
It is a single nucleotide change at the LINC01505 locus that has been linked to higher eudaimonic well-being in large studies.
Is this variant related to disease?
No, it is not associated with any known disease; the effect is on well-being only.
Can I change my risk?
The study does not suggest that changing your genotype will affect your well-being; genetics are descriptive not prescriptive.