rs10977830 - PTPRD variant and FAM89A link to antibodies
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- rs10977830 is in the intron of FAM89A and modestly raises antibody levels after COVID-19 vaccination
- The variant has no known effect on PTPRD function
- Evidence comes from a GWAS with 300 participants
Key takeaways
- This variant is located in the intron of FAM89A and has been linked to higher total antibody levels after SARS-CoV-2 vaccination [PMID 36451823].
- The association is modest with a reported effect size of 0.07, p=1e-9, based on about 300 participants.
- No direct evidence links this variant to PTPRD function or other traits.
What the research says The rs4543780 variant in the intron of FAM89A is associated with higher total antibody levels after inactivated SARS-CoV-2 vaccination [PMID 36451823]. The effect size is reported as 0.07, p=1e-9, in a sample of approximately 300 individuals.
Reported associations
- Total antibodies: the variant is associated with higher total antibody levels (effect size 0.07, p=1e-9) [PMID 36451823].
- PTPRD: no direct association reported for this gene [PMID 36451823].
Evidence quality The supplied studies do not report a direct trait association for rs10977830; the rsid appears via Frontiers in immunology 2022 study. The variant is linked to FAM89A expression and antibody levels but PTPRD function remains uncharacterized.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10977830 do?
It is a genetic marker in the intron of FAM89A that is modestly linked to higher antibody levels after COVID-19 vaccination but has no known effect on PTPRD function.
Is rs10977830 linked to PTPRD?
No, the variant does not affect PTPRD and there is no evidence linking it to this gene.
Can I change my diet because of rs10977830?
There are no lifestyle recommendations for this variant; it does not influence dietary choices or health behaviors.