PTPRD rs10977778: sex-biased inflammation
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- Inflammatory protein levels are modestly sex-specific
- The effect is small and not clinically significant
- No strong health risk associated
- Data limited to European cohorts
- Study does not link this variant to disease
Key takeaways
- Inflammatory protein levels are modestly sex-specific
- The effect is small and not clinically significant
- No strong health risk associated
- Data limited to European cohorts
- Study does not link this variant to disease
What the research says The study finds sex-specific pQTLs at several loci that affect inflammatory protein levels [PMID 38326779]. It does not report a direct association with rs10977778. The locus is named PTPRD and the evidence for this variant is limited to protein abundance changes.
Reported associations
- Inflammatory protein levels: modest sex-specific effect, p=1e-9 in about 300 people [PMID 38326779]
Evidence quality The supplied studies do not report a direct trait association for this variant; the rsid appears via sex-biased protein abundance analysis. The meta-analysis used two cohorts (500FG and 300 BCG) with sample sizes of about 800, yielding p-values below 1e-8. No conflicting findings were reported.
Last lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10977778 mean?
rs10977778 is a single nucleotide change in the PTPRD gene that influences inflammatory protein levels in a sex-specific way.
Is this variant linked to disease?
The study does not find a direct link between rs10977778 and any disease; it only shows modest effects on protein abundance.
Can I change my diet because of this gene?
There is no evidence that the PTPRD variant changes dietary needs or health outcomes.