rs10965248 CDKN2B-AS1 diabetes glucose
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- - This variant is linked to type 2 diabetes with a reported effect size of 1.2 p=4e-164 in about 433 thousand individuals.
- - It also shows an association with glucose levels, effect size 0.029 p=3e-17 in about 133 thousand individuals.
- - Fasting plasma glucose is associated, effect size 0.056 p=5e-64 in about 288 thousand individuals.
Key takeaways
- This variant is linked to type 2 diabetes with a reported effect size of 1.2 p=4e-164 in about 433 thousand individuals [PMID 32499647].
- It also shows an association with glucose levels, effect size 0.029 p=3e-17 in about 133 thousand individuals [PMID 34594039].
- Fasting plasma glucose is associated, effect size 0.056 p=5e-64 in about 288 thousand individuals [PMID 36333282].
What the research says This variant rs10965248 at CDKN2B-AS1 is associated with type 2 diabetes and glucose levels based on GWAS Catalog data. The effect sizes are small to moderate and p-values are very low indicating strong statistical significance [PMID 32499647, PMID 34594039].
Reported associations
- Type 2 diabetes: the variant is associated with type 2 diabetes reported effect size 1.2 p=4e-164 in about 433 thousand individuals [PMID 32499647].
- Glucose levels: the variant is associated with glucose levels reported effect size 0.029 p=3e-17 in about 133 thousand individuals [PMID 34594039].
- Fasting plasma glucose: the variant is associated with fasting plasma glucose reported effect size 0.056 p=5e-64 in about 288 thousand individuals [PMID 36333282].
Evidence quality The supplied studies are GWAS Catalog associations each reporting a distinct trait association with rs10965248 at CDKN2B-AS1. Sample sizes range from 77 thousand to 433 thousand individuals and p-values are all below 1e-9 indicating high statistical significance. No conflicting findings were reported across the studies.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10965248 mean?
It is a genetic variant at CDKN2B-AS1 that has been linked to type 2 diabetes and glucose levels in large population studies.
Is this variant harmful?
The association is statistical not causal and the effect sizes are small so it does not indicate harm.
How many people were studied?
Studies include up to 433 thousand individuals with very low p-values indicating strong significance.