rs10965235 (CDKN2B): endometriosis risk SNP
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Key takeaways
- This SNP is linked to higher risk of endometriosis
- The association has a small effect size (odds ratio 1.44) and very strong significance (p=5.57e-12)
- It lies in the CDKN2B gene region intron 16
- The variant may affect expression of nearby genes such as p15
Key takeaways This SNP is linked to higher risk of endometriosis The association has a small effect size (odds ratio 1.44) and very strong significance (p=5.57e-12) It lies in the CDKN2B gene region intron 16 The variant may affect expression of nearby genes such as p15
What the research says A genome-wide association study found that rs10965235 is associated with endometriosis in Japanese women, with an odds ratio of 1.44 and a p value of 5.57e-12 PMID 20601957. The SNP is located in intron 16 of the CDKN2B gene and may influence expression of nearby genes such as p15 [PMID 20601957].
Reported associations Endometriosis (odds ratio 1.44, p=5.57e-12) - the variant is linked to higher risk of this condition [PMID 20601957].
Evidence quality The study used a total of 1,907 Japanese individuals with endometriosis and 5,292 controls, reporting a strong association (p=5.57e-12). No conflicting findings were reported for this variant [PMID 20601957].
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10965235 mean?
It is a DNA change in the CDKN2B gene that has been linked to higher risk of endometriosis with an odds ratio of 1.44 and p=5.57e-12.
Is this variant common or rare?
The study reports it as a common SNP found in many people, but its effect on disease is modest.
Can I change my risk by lifestyle?
No specific lifestyle advice is linked to this variant; the evidence does not support any changes.