Expressive

rs10963602 (ADAMTSL1): angioedema risk

Key takeaways

  • This SNP is linked to angioedema when taking certain blood pressure drugs.
  • The reported effect size is 1.76 with a p value of 4e-6 in about 5000 people.
  • The risk allele is C.
  • Sample size was around 5000 individuals.

Key takeaways

  • This SNP is linked to angioedema when taking certain blood pressure drugs.
  • The reported effect size is 1.76 with a p value of 4e-6 in about 5000 people.
  • The risk allele is C.
  • Sample size was around 5000 individuals.

What the research says This variant rs10963602 is associated with angioedema when taking angiotensin converting enzyme inhibitor or angiotensin receptor blocker. The effect size is 1.76 and p value 4e-6 in about 5000 individuals [PMID 32080354].

Reported associations

  • Angioedema: risk allele C has a reported effect size of 1.76 p=4e-6 in about 5000 people [PMID 32080354]. Evidence quality The study used about 5000 individuals and found a strong association with angioedema when taking ACE inhibitors or ARBs. Effect size 1.76 p=4e-6. No other traits reported. [PMID 32080354].

Lifestyle considerations No lifestyle considerations on file for this variant.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Drug interactions

  • Angioedema risk with ACE inhibitors or ARBs Moderate

    ADAMTSL1 variant increases susceptibility to angioedema triggered by ACE inhibitors or ARBs.

    Discuss with your doctor before starting or continuing ACE-I or ARB medications.

Frequently asked questions

What does rs10963602 mean?

It is a genetic change in the ADAMTSL1 gene that can increase the risk of angioedema when you take certain blood pressure medicines.

Is this variant linked to heart disease?

No, the study only found an association with angioedema and not other conditions.

Can I avoid angioedema if I have this variant?

There is no recommendation to change your medication based on this finding alone.