rs10956249 (TRIB1): Blood Pressure Genetics

Key takeaways

• This variant was not individually reported as a significant finding in the one available study.
• A candidate analysis of 457 adult-derived blood pressure variants in 9,778 children found only two were significant; neither was at the TRIB1 locus.
• Polygenic risk scores built from many adult blood pressure variants do predict higher systolic blood pressure in children, with the effect growing stronger after puberty.
• No direct trait association for rs10956249 can be drawn from the available evidence.
• No lifestyle considerations specific to this variant are on file.

What the research says A candidate single-nucleotide polymorphism (SNP - a one-letter DNA variation) analysis and genome-wide association study (GWAS) of 9,778 children and adolescents in the Vanderbilt University Medical Center BioVU biobank tested 457 previously identified adult blood pressure variants for associations with systolic blood pressure (SBP) percentile during childhood; of those candidates, only rs1018148 in FBN1 and rs11105354 in ATP2B1 reached statistical significance, and rs10956249 was not individually reported. A polygenic risk score (PRS - a combined numeric score aggregating small effects from many variants) derived from adult blood pressure data was associated with higher childhood SBP percentile (β = 0.35 per SD of PRS, 95% CI 0.10-0.60; n = 9,778), with a significant interaction with age (P for interaction < 0.01), indicating the aggregate genetic contribution to blood pressure strengthens across adolescence.

Reported associations

• Systolic blood pressure (childhood): No direct association between rs10956249 and childhood SBP was reported in the available study; the variant was not individually named among findings in either the candidate SNP analysis or the GWAS.
• Polygenic risk and childhood SBP (general context): A multi-ancestry adult-derived PRS was associated with higher SBP percentile in 9,778 children (β = 0.35 per SD, 95% CI 0.10-0.60), with the effect strengthening significantly with age (P for interaction < 0.01). This reflects combined effects across many loci and does not isolate any contribution from rs10956249.

Evidence quality The single study on file examined 9,778 children from a single US biobank (VUMC BioVU), restricting generalizability across ancestries and healthcare settings. The candidate SNP analysis tested 457 adult-identified blood pressure variants, and no GWAS variant reached genome-wide significance, indicating the study was likely underpowered for novel variant discovery in this pediatric age range. rs10956249 was not individually reported, so no direct association between this specific SNP and any phenotype (observable trait) can be established from the available sources. The PRS finding (β = 0.35) is suggestive of cumulative genetic influence on childhood blood pressure but reflects aggregated contributions from many variants rather than this locus in isolation. The evidence base specific to rs10956249 is therefore absent.

Lifestyle considerations No lifestyle considerations on file for this variant.