rs10883928 - SH3PXD2A: cortical thickness link
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Key takeaways
- rs10883928 is associated with Vertex-wise cortical thickness (effect size 6.55, p = 6e-11)
- This variant lowers SH3PXD2A expression in whole blood and muscle tissue
- The GWAS signal is strong with a sample of about 33 000 people
Key takeaways
- rs10883928 is associated with Vertex-wise cortical thickness (effect size 6.55, p = 6e-11)
- This variant lowers SH3PXD2A expression in whole blood and muscle tissue
- The GWAS signal is strong with a sample of about 33 000 people
What the research says The GWAS catalog links rs10883928 to Vertex-wise cortical thickness (effect size 6.55, p = 6e-11) PMID 34910505. GTEx data shows reduced expression in whole blood and muscle tissue.
Reported associations
- Vertex-wise cortical thickness (effect size 6.55, p=6e-11) [PMID 34910505]
Evidence quality The GWAS used about 33 000 individuals and reported a strong signal with p=6e-11; no conflicting findings were found.
Tissue-specific expression effects
- SH3PXD2A: reduced expression in whole blood, muscle skeletal GTEx Portal.
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10883928 do?
It is a genetic variant that reduces SH3PXD2A expression and is linked to cortical thickness.
Is this variant related to brain disease?
The GWAS shows it affects cortical thickness but no direct link to disease is reported.
Can I change my risk with lifestyle?
No lifestyle considerations are on file for this variant.